GxEprs - Genotype-by-Environment Interaction in Polygenic Score Models
A novel PRS model is introduced to enhance the prediction
accuracy by utilising GxE effects. This package performs Genome
Wide Association Studies (GWAS) and Genome Wide Environment
Interaction Studies (GWEIS) using a discovery dataset. The
package has the ability to obtain polygenic risk scores (PRSs)
for a target sample. Finally it predicts the risk values of
each individual in the target sample. Users have the choice of
using existing models (Li et al., 2015)
<doi:10.1093/annonc/mdu565>, (Pandis et al., 2013)
<doi:10.1093/ejo/cjt054>, (Peyrot et al., 2018)
<doi:10.1016/j.biopsych.2017.09.009> and (Song et al., 2022)
<doi:10.1038/s41467-022-32407-9>, as well as newly proposed
models for genomic risk prediction (refer to the URL for more
details).